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pentobarbital will reduce the extent or outcome of triazolam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of.pentobarbital decreases levels of vandetanib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Prevent coadministration with powerful CYP3A4 inducers; these drugs lower publicity t